进行性系统性硬化症和类风湿关节炎患者T淋巴细胞集落生长减少。
Reduced T lymphoid colony growth in patients with progressive systemic sclerosis and rheumatoid arthritis.
作者信息
Winkelstein A, Bernstein M L, Stevens M A, Rodnan G P, Medsger T A, Dobson S A
出版信息
J Lab Clin Med. 1982 Aug;100(2):240-7.
T cell colony growth in semisolid medium, a sensitive indicator of disease-associated lymphoycte defects, was found to be depressed in patients with PSS and RA. In both disorders, more pronounced abnormalities were observed after incubation with suboptimal concentrations of the polyclonal mitogen PHA. Depletion of monocytes by adherence to plastic surfaces of addition of the prostaglandin synthetase inhibitor indomethacin did not correct the growth abnormality observed in PSS. Reduced colony-forming activity could not be attributed to serum inhibitory factors. The cellular abnormalities detected in patients with these connective tissue diseases were less pronounced than those found in SLE patients.
T细胞在半固体培养基中的集落生长是疾病相关淋巴细胞缺陷的敏感指标，结果发现系统性硬化症（PSS）和类风湿关节炎（RA）患者的该指标受到抑制。在这两种疾病中，用次优浓度的多克隆有丝分裂原PHA孵育后，观察到更明显的异常。通过黏附于塑料表面去除单核细胞或添加前列腺素合成酶抑制剂吲哚美辛，均不能纠正PSS中观察到的生长异常。集落形成活性降低不能归因于血清抑制因子。这些结缔组织疾病患者中检测到的细胞异常不如系统性红斑狼疮（SLE）患者中发现的明显。
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