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本文引用的文献

1
Anticancer and potential antiviral activity of complex inorganic compounds.复合无机化合物的抗癌及潜在抗病毒活性
J Med Chem. 1966 May;9(3):369-72. doi: 10.1021/jm00321a026.

金属螯合物作为抗癌剂。II. 6-巯基嘌呤和硫鸟嘌呤的钯和铂配合物的细胞毒性作用

Metal chelates as anti-cancer agents. II cytotoxic action of palladium and platinum complexes of 6-mercaptopurine and thioguanine.

作者信息

Das M, Livingstone S E

出版信息

Br J Cancer. 1978 Aug;38(2):325-8. doi: 10.1038/bjc.1978.205.

DOI:10.1038/bjc.1978.205
PMID:698049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009717/
Abstract

The metal complexes Pd(MP)2.2H2O, Pt(MP)2H2O (MPH=6-mercaptopurine), Pt(AMP2.3H2O and Pd3(AMP)4Cl2(AMPH).4H2O (AMPH=thioguanine) have been isolated. They were screened for anti-tumour activity in the L-1210 lymphoid leukaemia test system in mice. All 4 show marked anti-tumour activity, the complex Pt(AMP)2.3H2O giving a T/C of 185 at the optimum dosage. However, the anti-tumour activity of the metal complexes is somewhat less than that shown by the parent purines under the same conditions.

摘要

已分离出金属配合物Pd(MP)₂·2H₂O、Pt(MP)₂H₂O（MPH = 6 - 巯基嘌呤）、Pt(AMP)₂·3H₂O和Pd₃(AMP)₄Cl₂(AMPH)·4H₂O（AMPH = 硫鸟嘌呤）。在小鼠L - 1210淋巴细胞白血病测试系统中对它们进行了抗肿瘤活性筛选。所有这4种配合物都显示出显著的抗肿瘤活性，配合物Pt(AMP)₂·3H₂O在最佳剂量下的T/C为185。然而，在相同条件下，金属配合物的抗肿瘤活性略低于母体嘌呤所显示的活性。