Pichichero M E, Insel R A
J Infect Dis. 1982 Aug;146(2):243-8. doi: 10.1093/infdis/146.2.243.
The prevalence of natural mucosal antibody to the capsular polysaccharide (polyribosylribitolphosphate [PRP]) of Haemophilus influenzae type b in adults at multiple secretory sites and the relationship between natural serum and mucosal antibodies with respect to their amount and fine binding specificity were examined. All of 16 lactating women had antibody to PRP in serum and mammary samples; 11 of 14 studied had nasal antibody and 12 of 14 had salivary antibody. The amount of serum antibody to PRP in an individual positively correlated with the amount of mucosal antibody at each of the three secretory sites examined, and the antibody amount between certain secretions were also positively correlated. Antibody to PRP that is cross-reactive with Escherichia coli K100 or Streptococcus pneumoniae type 6 capsular polysaccharides was detected in the secretions of seven and one subjects, respectively, but the amount was not correlated with serum cross-reactive antibody.
研究了成人多个分泌部位针对b型流感嗜血杆菌荚膜多糖（多聚核糖基核糖醇磷酸酯[PRP]）的天然黏膜抗体的患病率，以及天然血清抗体与黏膜抗体在数量和精细结合特异性方面的关系。16名哺乳期妇女的血清和乳腺样本中均有针对PRP的抗体；14名研究对象中有11名有鼻抗体，14名中有12名有唾液抗体。个体血清中PRP抗体的量与所检测的三个分泌部位中每个部位的黏膜抗体量呈正相关，且某些分泌物之间的抗体量也呈正相关。分别在7名和1名受试者的分泌物中检测到了与大肠杆菌K100或6型肺炎链球菌荚膜多糖交叉反应的PRP抗体，但该量与血清交叉反应抗体不相关。
