Losito A, Cecchini C, Pittavini L, Zampi I
Nephron. 1982;30(4):324-7. doi: 10.1159/000182509.
DNA-anti-DNA cold precipitable complexes (CPC) isolated from 21 patients with systemic lupus erythematosus were tested for their ability to stimulate polymorphonuclear leukocyte (PMN) chemotaxis and to activate complement in vitro. The complexes activated complement in 20 out of 21 cases and stimulated PMN chemotaxis in 13 out of 21. The stimulation of chemotaxis was present in the majority of patients with renal involvement (10 out of 13) and active disease (8 out of 9), while being almost negligible in those without renal involvement or active disease. In patients studied sequentially, CPC-stimulated chemotaxis was reduced to nil with the remission of the disease. CPC appears to play a pathogenic role in active systemic lupus erythematosus with renal involvement.
对从21例系统性红斑狼疮患者中分离出的DNA - 抗DNA冷沉淀复合物（CPC）进行了检测，以评估其在体外刺激多形核白细胞（PMN）趋化性和激活补体的能力。在21例病例中，有20例复合物激活了补体，21例中有13例刺激了PMN趋化性。趋化性刺激在大多数有肾脏受累的患者（13例中的10例）和活动性疾病患者（9例中的8例）中存在，而在无肾脏受累或活动性疾病的患者中几乎可以忽略不计。在进行序贯研究的患者中，随着疾病缓解，CPC刺激的趋化性降至零。CPC似乎在伴有肾脏受累的活动性系统性红斑狼疮中起致病作用。
