系统性红斑狼疮中的多形核白细胞荧光及冷球蛋白吞噬作用

Polymorphonuclear leucocyte fluorescence and cryoglobulin phagocytosis in systemic lupus erythematosus.

作者信息

Losito A, Lorusso L

出版信息

Clin Exp Immunol. 1979 Mar;35(3):376-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537615/

Abstract

Peripheral blood polymorphonuclear leucocytes (PMN) and cryoglobulins were isolated from patients with systemic lupus erythematosus (SLE). Fluorescent inclusions were found in PMN. Normal donor PMN were incubated with the sera and cryoglobulins from SLE patients. In most cases inclusions were observed after incubation. The high incidence of anti-IgG activity in phagocytosed cryoglobulins confirms the importance of the rheumatoid factor in phagocytosis of immune complexes. It is concluded that phagocytosis of cryoglobulins supports the suggestion that cryoglobulins are a subpopulation of immune complexes.

摘要

从系统性红斑狼疮（SLE）患者中分离出外周血多形核白细胞（PMN）和冷球蛋白。在PMN中发现了荧光包涵体。将正常供体的PMN与SLE患者的血清和冷球蛋白一起孵育。在大多数情况下，孵育后观察到包涵体。吞噬的冷球蛋白中抗IgG活性的高发生率证实了类风湿因子在免疫复合物吞噬中的重要性。得出的结论是，冷球蛋白的吞噬支持了冷球蛋白是免疫复合物亚群的观点。

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本文引用的文献

1

Phagocytosis of particulate complexes of gamma-globulin and rheumatoid factor.γ-球蛋白与类风湿因子颗粒复合物的吞噬作用。

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Intracytoplasmic inclusions of immunoglobulins in rheumatoid arthritis and other diseases.类风湿关节炎及其他疾病中免疫球蛋白的胞浆内包涵体。

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Circulating immune complexes and complement activation in primary biliary cirrhosis.原发性胆汁性肝硬化中的循环免疫复合物与补体激活

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Phagocytosis of immune complexes by polymorphonuclear leucocytes in patients with Felty's syndrome.费尔蒂综合征患者多形核白细胞对免疫复合物的吞噬作用。

Clin Exp Immunol. 1977 Jun;28(3):413-25.

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Treatment of fulminant hepatic failure by polyacrylonitrile-membrane haemodialysis.用聚丙烯腈膜血液透析治疗暴发性肝衰竭

Lancet. 1977 Jul 2;2(8027):1-3. doi: 10.1016/s0140-6736(77)90001-0.

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