Losito A, Lorusso L
Clin Exp Immunol. 1979 Mar;35(3):376-9.
Peripheral blood polymorphonuclear leucocytes (PMN) and cryoglobulins were isolated from patients with systemic lupus erythematosus (SLE). Fluorescent inclusions were found in PMN. Normal donor PMN were incubated with the sera and cryoglobulins from SLE patients. In most cases inclusions were observed after incubation. The high incidence of anti-IgG activity in phagocytosed cryoglobulins confirms the importance of the rheumatoid factor in phagocytosis of immune complexes. It is concluded that phagocytosis of cryoglobulins supports the suggestion that cryoglobulins are a subpopulation of immune complexes.
从系统性红斑狼疮（SLE）患者中分离出外周血多形核白细胞（PMN）和冷球蛋白。在PMN中发现了荧光包涵体。将正常供体的PMN与SLE患者的血清和冷球蛋白一起孵育。在大多数情况下，孵育后观察到包涵体。吞噬的冷球蛋白中抗IgG活性的高发生率证实了类风湿因子在免疫复合物吞噬中的重要性。得出的结论是，冷球蛋白的吞噬支持了冷球蛋白是免疫复合物亚群的观点。
