van der Putte S C, Schuurman H J, Toonstra J
Br J Dermatol. 1982 Sep;107(3):293-300. doi: 10.1111/j.1365-2133.1982.tb00359.x.
Monoclonal antibodies to human T-cell membrane antigens were used to evaluate the immunological phenotype of the tumour cells in two cases of a recently described cutaneous T-cell lymphoma of 'multilobated' type. In one case the distinctive abnormal blast cells expressed positivity for OKT6, anti-HTAI, OKT4 and Leu-3a, and showed binding capacity for peanut agglutinin (PNA). These are properties normally displayed by immature cortical thymocytes. The antigen expression of the abnormal blast cells in the other case was OKT3, Leu-I, OKT4, Leu-3a in the absence of PNA-binding; these properties bear more resemblance to more mature T-inducer/helper cells. When combined with consideration of the morphological aspects we suggest that in both cases the abnormal cells represented precursor T-lymphocytes.
利用针对人T细胞膜抗原的单克隆抗体，对两例最近描述的“多叶型”皮肤T细胞淋巴瘤病例中的肿瘤细胞免疫表型进行了评估。在一例中，独特的异常母细胞对OKT6、抗HTAI、OKT4和Leu-3a呈阳性反应，并显示出对花生凝集素（PNA）的结合能力。这些是未成熟皮质胸腺细胞通常表现出的特性。另一例中异常母细胞的抗原表达为OKT3、Leu-1、OKT4、Leu-3a，且无PNA结合；这些特性与更成熟的T诱导/辅助细胞更为相似。结合形态学方面的考虑，我们认为在这两例中异常细胞均代表前体T淋巴细胞。
