Weiss L M, Bindl J M, Picozzi V J, Link M P, Warnke R A
Blood. 1986 Feb;67(2):474-8.
A series of 26 lymphoblastic lymphomas (LLs) and 13 T cell acute lymphoblastic leukemias (ALLs) were investigated using a battery of monoclonal antibodies applied to tissue frozen sections. Twenty-one of the LLs were of T lineage. All but one of the T cell LLs were of immature thymic phenotype, mostly corresponding to stage II cortical thymocyte development. The T cell LLs expressed Leu-1 in 100%, Leu-4 and Leu-9 in 95%, and Leu-5 in 85% of the cases. The high percentage of Leu-4 expression in this series is probably due to detection of cytoplasmic antigen with our methods. One LL was of pre-B or B cell and two cases were of common ALL phenotype. Two cases were of undefined phenotype, expressing markers of both B and T cell differentiation. Pediatric cases showed a greater tendency toward T cell phenotype than did adult cases. The cases of T cell ALL were immunophenotypically similar to the cases of T cell LL but showed a tendency toward a more immature phenotype.
使用一系列单克隆抗体对26例淋巴母细胞淋巴瘤（LL）和13例T细胞急性淋巴细胞白血病（ALL）的组织冰冻切片进行了研究。21例LL为T细胞系。除1例T细胞LL外，其余均为未成熟胸腺表型，大多对应于皮质胸腺细胞发育的II期。T细胞LL在100%的病例中表达Leu-1，在95%的病例中表达Leu-4和Leu-9，在85%的病例中表达Leu-5。本系列中Leu-4高表达可能是由于我们的方法检测到了细胞质抗原。1例LL为前B或B细胞型，2例为普通ALL表型。2例表型不明确，表达B和T细胞分化的标志物。儿科病例比成人病例更倾向于T细胞表型。T细胞ALL病例在免疫表型上与T细胞LL病例相似，但显示出更不成熟表型的倾向。
