Antonenko S G, Berdinskikh N K, Shishko E D, Okolot E N
Vopr Onkol. 1985;31(5):48-52.
The study was concerned with the effect of human ceruloplasmin on blastogenic reaction of lymphocytes (BRL) and cyclic nucleotide level in murine organs in the course of Lewis lung carcinoma development. Both ceruloplasmin and an immunomodulator--zymosan--were found to raise the level of cAMP and to lower that of cGMP in the immunocompetent organs (thymus and spleen) of tumor-bearing mice at all stages of the investigation. The results point to an immunomodulating action of human ceruloplasmin involved in tumor growth and the role played by cyclic nucleotides in the process.
该研究关注的是在Lewis肺癌发展过程中，人铜蓝蛋白对淋巴细胞增殖反应（BRL）以及小鼠器官中环核苷酸水平的影响。在整个研究过程中，发现在荷瘤小鼠的免疫活性器官（胸腺和脾脏）中，铜蓝蛋白和一种免疫调节剂——酵母聚糖，均能提高cAMP水平并降低cGMP水平。结果表明，人铜蓝蛋白参与肿瘤生长的免疫调节作用以及环核苷酸在此过程中所起的作用。
