富含脯氨酸多肽对移植物抗宿主反应中供体细胞的影响。
Effect of proline-rich polypeptide on donor cells in graft-versus-host reaction.
作者信息
Zimecki M, Janusz M, Starościk K, Lisowski J, Wieczorek Z
出版信息
Immunology. 1982 Sep;47(1):141-7.
The effect of a proline-rich polypeptide (PRP) isolated from early sheep colostrum on the graft-versus-host (GvH) reaction was studied. Unfractionated thymocytes, treated with PRP in vivo or in vitro, acquired the ability to elicit the GvH reaction. In fact PRP elicited GvH reactivity in cortisone-sensitive thymocytes and cortisone-sensitive thymocytes become cortisone-resistant after incubation with PRP. On the other hand, some of the cortisone-resistant thymocytes become cortisone-sensitive when treated with PRP and the ability to induce the GvH reaction was reduced.
研究了从早期羊初乳中分离出的富含脯氨酸的多肽（PRP）对移植物抗宿主（GvH）反应的影响。未分级的胸腺细胞，无论在体内还是体外经PRP处理后，都获得了引发GvH反应的能力。实际上，PRP在对可的松敏感的胸腺细胞中引发了GvH反应性，并且对可的松敏感的胸腺细胞在与PRP孵育后变得对可的松具有抗性。另一方面，一些对可的松具有抗性的胸腺细胞在用PRP处理后变得对可的松敏感，并且诱导GvH反应的能力降低。
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