Raichvarg D, Siou G, Dubreuil A, Bonnaire Y, Brossard C, Boudène C
J Hyg Epidemiol Microbiol Immunol. 1982;26(2):112-6.
The lipopolysaccharide of Haemophilus influenzae is presumed to have a toxic effect on the tracheal epithelium, and then induce a bronchial obstruction. This activity of LPS was studied in vitro on the ciliary beat using a photo-oscillographic apparatus, and in vivo on the rabbit trachea. Neither modification of ciliary beat frequency, nor epithelial damage in the rabbit trachea was observed after a single administration of LPS. In contrast, histopathologic changes were observed in vivo when the intratracheal administration of H. influenzae LPS was followed 24 h later by an intravenous injection of the same LPS. These experimental models seem thus to implicate a Shwartzman type cellular necrosis in the trachea in vivo in the absence of a direct toxic effect of endotoxin itself on trachea in vivo or in vitro.
流感嗜血杆菌的脂多糖被认为对气管上皮有毒性作用，进而导致支气管阻塞。使用光振荡描记仪在体外对纤毛摆动研究了脂多糖的这种活性，并在体内对兔气管进行了研究。单次给予脂多糖后，未观察到兔气管纤毛摆动频率的改变或上皮损伤。相反，当气管内给予流感嗜血杆菌脂多糖24小时后静脉注射相同的脂多糖时，在体内观察到了组织病理学变化。因此，这些实验模型似乎表明，在体内气管中存在施瓦茨曼型细胞坏死，而内毒素本身在体内或体外对气管没有直接毒性作用。
