Tamaki S, Nakajima H, Murakami T, Yui Y, Kambara H, Kadota K, Yoshida A, Kawai C, Tamaki N, Mukai T, Ishii Y, Torizuka K
Circulation. 1982 Nov;66(5):994-1001. doi: 10.1161/01.cir.66.5.994.
We evaluated emission computed tomography (ECT) for thallium-201 (201TI) myocardial imaging in estimating infarct size (IS). In 18 patients in whom IS was estimated enzymatically at the time of the acute episode, planar 201TI perfusion scintigraphy and ECT with a rotating gamma camera were performed 4 weeks after the first myocardial infarction. From the size of 201TI perfusion defects, the infarct area in planar images and the infarct volume in reconstructed ECT images were measured by computerized planimetry. When scintigraphic IS was compared with the accumulated creatine kinase-MB isoenzyme release (CK-MBr), infarct volume determined from ECT correlated closely with CK-MBr (r = 0.89), whereas infarct area measured from planar images correlated less satisfactorily with the enzymatic IS (for an average infarct area from three views, r = 0.69; for the largest infarct area, r = 0.73). Although conventional scintigraphic evaluation is useful for detecting and localizing infarction, quantification of ischemic injury with this two-dimensional technique has a significant inherent limitation. The ECT approach can provide a more accurate three-dimensional quantitative estimate of infarction, and can corroborate the enzymatic estimate of IS.
我们评估了发射计算机断层扫描（ECT）用于铊 - 201（²⁰¹Tl）心肌成像以估计梗死面积（IS）的情况。在18例急性发作时通过酶法估计梗死面积的患者中，首次心肌梗死后4周进行了平面²⁰¹Tl灌注闪烁显像和使用旋转γ相机的ECT检查。根据²⁰¹Tl灌注缺损的大小，通过计算机辅助平面测量法测量平面图像中的梗死面积和重建ECT图像中的梗死体积。当将闪烁显像法测得的梗死面积与累积肌酸激酶 - MB同工酶释放量（CK - MBr）进行比较时，由ECT确定的梗死体积与CK - MBr密切相关（r = 0.89），而从平面图像测量的梗死面积与酶法测得的梗死面积相关性较差（从三个视角测得的平均梗死面积，r = 0.69；最大梗死面积，r = 0.73）。尽管传统的闪烁显像评估对于检测和定位梗死很有用，但用这种二维技术对缺血损伤进行量化存在显著的固有局限性。ECT方法可以提供更准确的梗死三维定量估计，并能证实酶法对梗死面积的估计。
