Germano G, Kavanagh P B, Berman D S
Cedars-Sinai Medical Center Los Angeles, CA 90048, USA.
Int J Card Imaging. 1997 Aug;13(4):337-46. doi: 10.1023/a:1005815206195.
We have developed a software suite that automatically selects, analyses, quantitates and displays all the key image data in a myocardial perfusion SPECT study.
The files automatically selected (upon specification of the patient name) are rest and stress projections, rest and stress short axis and gated short axis files, and all 'snapshot' files. The projection data sets are presented in cine mode for evaluation of patient motion, while the lung/heart ratio at rest and stress is calculated from regions of interest (ROIs) that are automatically derived and overlayed on the LAO 45 images. Left ventricular (LV) cavity volumes at rest and stress are calculated from the short axis data sets, and the related transient ischemic dilation (TID) ratio derived and displayed. Quantitative measurements of global (ejection fraction) and regional function parameters are performed from the gated short axis dataset. All algorithms use the C++, X-Windows and OSF-Motif standards. The overall suite executes in less than 1 minute on a SunSPARC5 with 32 Mb of RAM and no proprietary hardware.
The software was validated on 144 patients (118 rest 201T1/post-stress 99mTc-sestamibi, 18 post-stress 99mTC-sestamibi, 8 rest 201Tl) acquired on a 90 degrees dual detector (ADAC Vertex, 91 patients) and a triple detector camera (Picker Prism 3000, 53 patients). Overall, the individual algorithms for the analysis of projection, short axis and gated short axis images were successful in 622/660 (94.2%) of the images. In 80.5% of the patients (73/91 + 43/53) all algorithms executed successfully, without significant difference in success rates for 201Tl versus 99mTc-sestamibi images.
Our automated approach to myocardial perfusion SPECT analysis and review is highly successful, intrinsically reproducible, and can produce time and cost savings while improving accuracy in a clinical or teleradiology-type environment.
我们开发了一套软件，可自动选择、分析、定量并显示心肌灌注单光子发射计算机断层扫描（SPECT）研究中的所有关键图像数据。
自动选择的文件（指定患者姓名后）包括静息和负荷投影图像、静息和负荷短轴及门控短轴文件，以及所有“快照”文件。投影数据集以电影模式呈现，用于评估患者运动情况，同时根据自动生成并叠加在左前斜45°图像上的感兴趣区域（ROI）计算静息和负荷状态下的肺/心比值。根据短轴数据集计算静息和负荷状态下的左心室（LV）腔容积，并得出相关的短暂性心肌缺血性扩张（TID）比值并显示。从门控短轴数据集中对整体（射血分数）和局部功能参数进行定量测量。所有算法均采用C++、X-Windows和OSF-Motif标准。在配备32 Mb内存且无专有硬件的SunSPARC5上，整个软件套件执行时间不到1分钟。
该软件在144例患者中得到验证（118例静息201Tl/负荷后99mTc-司他米比，18例负荷后99mTc-司他米比，8例静息201Tl），这些患者的数据采集于90°双探测器（ADAC Vertex，91例患者）和三探测器相机（Picker Prism 3000，53例患者）。总体而言，用于分析投影、短轴和门控短轴图像的各个算法在660幅图像中的622幅（94.2%）上成功运行。在80.5%的患者（73/91 + 43/53）中，所有算法均成功执行，201Tl与99mTc-司他米比图像的成功率无显著差异。
我们对心肌灌注SPECT分析和复查的自动化方法非常成功，具有内在的可重复性，在临床或远程放射学类型的环境中，既能节省时间和成本，又能提高准确性。
