急性病毒性肝炎中的淋巴细胞亚群

Lymphocyte subpopulation in acute viral hepatitis.

作者信息

Datta U, Sehgal S, Pal S R, Dhall K, Singh S, Datta D V

出版信息

Gut. 1982 Nov;23(11):927-30. doi: 10.1136/gut.23.11.927.

DOI:10.1136/gut.23.11.927

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1419809/

Abstract

Studies of peripheral blood lymphocytes were performed in 41 patients with acute viral hepatitis, in grade III-IV coma; 16 patients were in the third trimester of pregnancy. There were significant reductions in absolute lymphocyte count and T cell number in patients who succumbed to the disease, when compared with those who survived. B cell counts were similar in the two groups and migration inhibition test with BCG antigen was normal. It is postulated that a decrease in the number of cells interacting in cell-mediated immune reactions is related to prognosis in acute viral hepatitis.

摘要

对41例处于III - IV级昏迷的急性病毒性肝炎患者进行了外周血淋巴细胞研究；其中16例处于妊娠晚期。与存活患者相比，死于该疾病的患者绝对淋巴细胞计数和T细胞数量显著减少。两组的B细胞计数相似，用卡介苗抗原进行的迁移抑制试验正常。据推测，细胞介导免疫反应中相互作用的细胞数量减少与急性病毒性肝炎的预后有关。

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本文引用的文献

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Human lymphocyte migration as a parameter of hypersensitivity.人类淋巴细胞迁移作为超敏反应的一个参数。

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Viral hepatitis during pregnancy. Severity and effect on gestation.妊娠期病毒性肝炎。严重程度及对妊娠的影响。

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T and B lymphocytes in acute and chronic hepatitis.急性和慢性肝炎中的T淋巴细胞和B淋巴细胞

Clin Immunol Immunopathol. 1974 Apr;2(3):353-60. doi: 10.1016/0090-1229(74)90053-1.

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Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases.处于各种人类疾病状态下的胸腺来源的玫瑰花结形成细胞：癌症、淋巴瘤、细菌和病毒感染以及其他疾病。

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A one-stage procedure for isolation of granulocytes and lymphocytes from human blood. General sedimentation properties of white blood cells in a 1g gravity field.一种从人血中分离粒细胞和淋巴细胞的一步法。白细胞在1g重力场中的一般沉降特性。

Scand J Clin Lab Invest Suppl. 1968;97:51-76.

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Hepatitis B virus infection in northern India. Prevalence, subtypes, and seasonal variation.印度北部的乙型肝炎病毒感染。患病率、亚型及季节变化。

Bull World Health Organ. 1974;51(1):13-7.

9

Thymus-dependent lymphocyte function in patients with hepatitis-associated antigen.肝炎相关抗原患者的胸腺依赖性淋巴细胞功能

Lancet. 1972 Oct 21;2(7782):850-3. doi: 10.1016/s0140-6736(72)92212-x.

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A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization.一群带有抗原-抗体-补体复合物膜受体的淋巴细胞。I. 分离与特性鉴定。

J Exp Med. 1970 Oct 1;132(4):702-20. doi: 10.1084/jem.132.4.702.

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