Salonen R, Ilonen J, Reunanen M, Salmi A
J Neurol Sci. 1982 Aug;55(2):197-206. doi: 10.1016/0022-510x(82)90101-0.
Interferon (IFN) production by peripheral blood mononuclear cells after induction with one purified and three crude viral antigens was studied in 29 patients with stable multiple sclerosis (MS) and 29 healthy controls. Antiviral substance produced was characterized as interferon-alpha. MS patients produced significantly less IFN-alpha after induction with mumps and purified measles virus antigens and the same tendency was seen after induction with rubella virus antigen. However, when herpes simplex virus antigen was used as the stimulating agent, no difference was seen between MS patients and controls. The decreased ability to produce IFN-alpha was associated with the histocompatibility antigen Dw2. Control subjects positive for Dw2 also produced less IFN-alpha than Dw2-negative controls. In conclusion, we suggest that the observed impaired interferon-alpha production in MS is at least partially due to a high prevalence of Dw2 antigen in this disease.
我们研究了29例稳定型多发性硬化症（MS）患者和29名健康对照者外周血单个核细胞在用一种纯化病毒抗原和三种粗制病毒抗原诱导后产生干扰素（IFN）的情况。所产生的抗病毒物质被鉴定为α干扰素。MS患者在用腮腺炎病毒和纯化麻疹病毒抗原诱导后产生的α干扰素显著减少，在用风疹病毒抗原诱导后也呈现相同趋势。然而，当使用单纯疱疹病毒抗原作为刺激剂时，MS患者和对照者之间未观察到差异。产生α干扰素能力的下降与组织相容性抗原Dw2相关。Dw2阳性的对照者产生的α干扰素也比Dw2阴性的对照者少。总之，我们认为在MS中观察到的α干扰素产生受损至少部分归因于该疾病中Dw2抗原的高患病率。
