Laky M, Mota G, Gheţie V
Mol Immunol. 1982 Aug;19(8):1029-36. doi: 10.1016/0161-5890(82)90311-x.
Mouse lymphoid cells treated with multivalent hybrid antibody consisting of rabbit IgG anti-T antibody and rabbit IgG anti-chicken red blood cell antibody formed rosettes and killed specifically chicken red blood cells. The attachment and killing of chicken red blood cells is due to multivalent hybrid antibody which is able to link with one antibody specificity (anti-T) the T-lymphocytes and with the other one the chicken red blood cell surface antigen(s). Some indirect results seem to suggest natural killer cells as a candidate for the multivalent hybrid antibody-induced cytolytic effects. Multivalent hybrid antibody can be a useful alternative to mitogen for assaying specifically the cytotoxic potential of various cell populations pre-existing in normal organisms and requiring only a link to the target cells to reveal their killing ability.
用由兔IgG抗T抗体和兔IgG抗鸡红细胞抗体组成的多价杂交抗体处理的小鼠淋巴细胞形成了玫瑰花结，并特异性地杀死了鸡红细胞。鸡红细胞的附着和杀伤是由于多价杂交抗体，它能够将T淋巴细胞与一种抗体特异性（抗T）相连，而将鸡红细胞表面抗原与另一种抗体特异性相连。一些间接结果似乎表明自然杀伤细胞是多价杂交抗体诱导的细胞溶解作用的候选者。多价杂交抗体可以作为有丝分裂原的一种有用替代物，用于特异性测定正常生物体中预先存在的各种细胞群体的细胞毒性潜力，并且只需要与靶细胞相连就能揭示它们的杀伤能力。
