通过人免疫球蛋白包被的红细胞溶血检测到的抗人免疫球蛋白抗体。

Antibodies to human immunoglobulin detected by hemolysis of human immunoglobulin-coated red blood cells.

作者信息

Takahashi H, Terasaki P I, Cicciarelli J C, Iwaki Y, Nasu H, Slyker T

出版信息

Tissue Antigens. 1981 Jan;17(1):67-74. doi: 10.1111/j.1399-0039.1981.tb00668.x.

DOI:10.1111/j.1399-0039.1981.tb00668.x

Abstract

A hemolysis assay was developed to detect alloantibodies to human immunoglobulin. A total of 1035 serum samples was tested. Anti-IgM antibodies were found in 8% of 59 normal persons and in 13% of 439 multiparous women, with the highest incidence of 67% in 341 dialysis patients. Although the anti-IgM antibodies were inhibited by both IgM and IgG, it appeared that they were also inhibited by F(ab')2 bu not by Fc. Anti-IgG antibodies were more strongly inhibited by Fc than F(ab')2. These results suggest that anti-IgM antibodies might be analogous to antiidiotypic antibodies directed to F(ab')2, whereas anti-IgG antibodies tend to have greater reactivity to Fc.

摘要

开发了一种溶血试验以检测针对人免疫球蛋白的同种抗体。共检测了1035份血清样本。在59名正常人中有8%发现了抗IgM抗体，在439名经产妇中有13%发现了抗IgM抗体，在341名透析患者中发生率最高，为67%。尽管抗IgM抗体被IgM和IgG均抑制，但似乎它们也被F(ab')2抑制而不被Fc抑制。抗IgG抗体被Fc抑制的程度比被F(ab')2抑制的程度更强。这些结果表明，抗IgM抗体可能类似于针对F(ab')2的抗独特型抗体，而抗IgG抗体往往对Fc具有更高的反应性。