[24,25-二羟胆钙化醇在大鼠运动不足状态下骨矿化中的作用]
[Role of 24,25-dihydroxycholecalciferol in bone mineralization under hypokinesia in the rat].
作者信息
Sergeev I N, Blazheevich N V, Belakovskiĭ M S, Spirichev V B, Ushakov A S
出版信息
Kosm Biol Aviakosm Med. 1982 Sep-Oct;16(5):74-7.
PMID:6983003
Abstract
24,25-Dihydroxycholecalciferol, an active D3 vitamin metabolite, at a dose of 1.25 microgram/day/animal prevents bone osteoporotic changes, effectively stimulating the diaphyseal and epiphyseal mineralization, and corrects hypocalcemia of hypokinetic rats. 24,25(OH)2D3 at the above dose does not increase nephrocalcinosis or does not produce the toxic effect as measured by body mass variations.
摘要
24,25-二羟胆钙化醇，一种活性维生素D3代谢产物，以1.25微克/天/动物的剂量可预防骨质疏松性骨变化，有效刺激骨干和骨骺矿化，并纠正运动减少大鼠的低钙血症。上述剂量的24,25(OH)2D3不会增加肾钙质沉着，也不会产生以体重变化衡量的毒性作用。
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