淋巴性白血病和非霍奇金淋巴瘤中Ia样抗原的表达及其与其他表面标志物的相关性。

Expression of Ia-like antigen in lymphatic leukaemias and non-hodgkin lymphomas in correlation with other surface markers.

作者信息

Bergmann L, Mitrou P S, Cherdron T, Holloway K, Jost J, Timm V, Zerth G

出版信息

Scand J Haematol. 1982 Sep;29(3):224-34. doi: 10.1111/j.1600-0609.1982.tb00587.x.

DOI:10.1111/j.1600-0609.1982.tb00587.x

Abstract

Ia-like antigen, surface Ig, E-rosettes, mouse red blood cell rosettes and further surface markers were investigated in 88 specimens from 69 patients with various lymphocytic leukaemias and non-Hodgkin lymphomas. Ia-like antigen was detectable in all cases of sIg+ leukaemias and lymphomas. E-Ia+sIg-leukaemias, especially CLL and lymphomas were interpreted as B-cell neoplasias, which either did not produce sIg or expressed it in undetectable amounts. E+Ia+sIg+ malignant lymphocytes represented a B-cell population with antibody activity of sIg to SRBC. In the present series 9.5% of all B-cell leukaemias and lymphomas demonstrated this phenotype. Whereas ALL may possess Ia-like antigen, the vast majority of mature T-cell lymphomas are lacking it. In the present series 2 T-cell lymphomas expressed Ia-like antigen and did not contain TdT (E+Ia+sIg-TdT-). These lymphomas are probably derived from a stimulated T-cell clone synthesizing Ia-like antigen.

摘要

在来自69例各种淋巴细胞白血病和非霍奇金淋巴瘤患者的88份标本中，研究了Ia样抗原、表面免疫球蛋白、E花环、小鼠红细胞花环以及其他表面标志物。在所有sIg⁺白血病和淋巴瘤病例中均可检测到Ia样抗原。E⁺Ia⁻sIg⁻白血病，尤其是慢性淋巴细胞白血病和淋巴瘤被解释为B细胞肿瘤，它们要么不产生sIg，要么以检测不到的量表达sIg。E⁺Ia⁺sIg⁺恶性淋巴细胞代表具有针对绵羊红细胞的sIg抗体活性的B细胞群体。在本系列中，所有B细胞白血病和淋巴瘤中有9.5%表现出这种表型。虽然急性淋巴细胞白血病可能具有Ia样抗原，但绝大多数成熟T细胞淋巴瘤缺乏该抗原。在本系列中，2例T细胞淋巴瘤表达Ia样抗原且不含有末端脱氧核苷酸转移酶（E⁺Ia⁺sIg⁻TdT⁻）。这些淋巴瘤可能源自合成Ia样抗原的受刺激T细胞克隆。