Burns G F, Cawley J C
Clin Exp Immunol. 1980 Jan;39(1):83-9.
Mouse-rosette formation was investigated in a variety of leukaemias and lymphomas, and it was found that this phenomenon was restricted to the B lymphocytes of chronic lymphocytic leukaemia and hairy-cell leukaemia. Eighteen of nineteen cases of chronic lymphocytic leukaemia expressed the mouse receptor, but only eight of fifteen cases of hairy-cell leukaemia showed significant mouse rosette formation by peripheral blood cells. A much higher percentage of splenic hairy cells, compared with peripheral blood cells, formed mouse rosettes, but receptor expression was found to be dependent on the surface immunoglobulin (SIg) phenotype. Cases forming mouse rosettes had multiple heavy chain isotypes including IgD on the surface, but the ontogenically more mature SIgG-only cells from other cases failed to form rosettes, whether from peripheral blood or spleen. Cultured hairy cells lost the ability to form mouse rosettes, and receptor expression by peripheral blood hairy cells fluctuated widely in the days following splenectomy. The results suggest that the mouse erythrocyte receptor is an early marker in B cell differentiation and that receptor expression by individual cells may depend on the age of the cell.
在多种白血病和淋巴瘤中研究了小鼠红细胞花环形成，发现这种现象仅限于慢性淋巴细胞白血病和毛细胞白血病的B淋巴细胞。19例慢性淋巴细胞白血病中有18例表达小鼠受体，但15例毛细胞白血病中只有8例外周血细胞显示出明显的小鼠红细胞花环形成。与外周血细胞相比，脾毛细胞形成小鼠红细胞花环的比例要高得多，但发现受体表达取决于表面免疫球蛋白（SIg）表型。形成小鼠红细胞花环的病例表面有多种重链同种型，包括IgD，但来自其他病例的个体发生上更成熟的仅SIgG细胞未能形成花环，无论是来自外周血还是脾脏。培养的毛细胞失去了形成小鼠红细胞花环的能力，脾切除术后数天外周血毛细胞的受体表达波动很大。结果表明，小鼠红细胞受体是B细胞分化的早期标志物，单个细胞的受体表达可能取决于细胞的年龄。
