过敏性紫癜中的血清补体成分
Serum complement components in Henoch-Schönlein purpura.
作者信息
Garcia-Fuentes M, Martin A, Chantler C, Williams D G
出版信息
Arch Dis Child. 1978 May;53(5):417-9. doi: 10.1136/adc.53.5.417.
Abstract
Serum levels of C1q, C4, C3, C5, factor B, and properdin were measured in patients with Henoch-Schönlein purpura (HSP). In the cases of acute HSP, 9 of 23 (39%) had a low CH50, and 5 of 17 (30%) a low properdin; C1q, C4, and C3 levels were not depressed. In 10 cases with chronic nephritis following HSP, complement components were normal except for 2 with reduced C4 and one with low properdin. These findings confirm that complement activation occurs in HSP; the low serum levels of properdin in the acute group indicate that there is activation of the alternative pathway in these patients.
摘要
对过敏性紫癜（HSP）患者测定血清C1q、C4、C3、C5、B因子和备解素水平。在急性HSP患者中，23例中有9例（39%）CH50水平低，17例中有5例（30%）备解素水平低；C1q、C4和C3水平未降低。在10例HSP后发生慢性肾炎的患者中，除2例C4降低和1例备解素水平低外，补体成分均正常。这些发现证实HSP中存在补体激活；急性组中备解素血清水平低表明这些患者的替代途径被激活。
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本文引用的文献
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