新生儿肺部脂肪酸与脂质过氧化之间的关系。
Relationship between fatty acids and lipid peroxidation in lungs of neonates.
作者信息
Kehrer J P, Autor A P
出版信息
Biol Neonate. 1978;34(1-2):61-7. doi: 10.1159/000241106.
Triglycerides from the lungs of neonatal rats and mice were found to contain large amounts of the polyunsaturated fatty acids, arachidonate (20:4) and docosahexaeonoate (22:6). These fatty acids were diminished or absent in the triglycerides from the lungs of adult rats and mice and both neonatal and adult guinea pigs. No age-related changes were observed in the fatty acid composition of lung phospholipids in any of these species. The presence of arachidonic acid and docosahexaenoic acid in lung triglycerides correlated with the ability of these lungs to peroxidize lipids in vitro in all species. Depletion of lung triglycerides in neonatal rats by fasting abolished this lipid peroxidizing activity.
研究发现，新生大鼠和小鼠肺中的甘油三酯含有大量多不饱和脂肪酸，即花生四烯酸（20:4）和二十二碳六烯酸（22:6）。在成年大鼠和小鼠以及新生和成年豚鼠的肺甘油三酯中，这些脂肪酸含量减少或不存在。在所有这些物种中，肺磷脂的脂肪酸组成均未观察到与年龄相关的变化。在所有物种中，肺甘油三酯中花生四烯酸和二十二碳六烯酸的存在与这些肺组织在体外使脂质过氧化的能力相关。通过禁食耗尽新生大鼠肺中的甘油三酯可消除这种脂质过氧化活性。
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