Bolton C, Borel J F, Cuzner M L, Davison A N, Turner A M
J Neurol Sci. 1982 Nov;56(2-3):147-53. doi: 10.1016/0022-510x(82)90138-1.
Cyclosporin A (CsA), an immunosuppressant which acts selectively on antigen-responding T cells, was tried in the treatment of experimental allergic encephalomyelitis (EAE). The drug was highly effective in preventing the appearance of clinical and pathological signs of EAE in rats, guinea pigs and monkeys. Treatment of the established disease also reduced the incidence and severity of symptoms, and significantly reduced the number of inflammatory lesions in the central nervous system.
环孢素A（CsA）是一种选择性作用于对抗抗原的T细胞的免疫抑制剂，曾被用于实验性变应性脑脊髓炎（EAE）的治疗。该药物在预防大鼠、豚鼠和猴子出现EAE的临床和病理体征方面非常有效。对已发病的治疗也降低了症状的发生率和严重程度，并显著减少了中枢神经系统炎症病变的数量。
