Baden L, Weiss S T, Thomas H E, Sparrow D
Arch Environ Health. 1982 Nov-Dec;37(6):365-9. doi: 10.1080/00039896.1982.10667593.
Previous cross-sectional studies have shown age trends in electrocardiographic wave patterns, including leftward shift in frontal plane axis and decreases in R, S, and T wave amplitudes with age. The effects of smoking on electrocardiographic measurements have also been examined. Findings of several studies vary and include possible smoking-induced changes in T wave amplitude and frontal plane axis measurements. To examine both cross-sectionally and longitudinally the effects of cigarette smoking on electrocardiographic measurements, serial recordings obtained 5 yr apart were taken from 702 healthy male participants of the Normative Aging Study, who were 23-74 yr of age at their first examination. These men were classified as current smokers (at both baseline and follow-up examinations, N = 291), former smokers (men who stopped smoking prior to the baseline examination, N = 203), or never smokers (at any time, N = 208). At baseline, P-R interval duration was shorter in current smokers than in former or never smokers. Longitudinal results indicated that R, S, and T wave amplitudes decreased at greater rates in smokers than in nonsmokers. These findings suggest that changes in the electrocardiogram attributed to aging may be modified by smoking.
以往的横断面研究显示了心电图波形的年龄趋势，包括额面电轴左偏以及随着年龄增长R波、S波和T波振幅降低。吸烟对心电图测量的影响也已得到研究。几项研究的结果各不相同，包括吸烟可能导致的T波振幅和额面电轴测量值的变化。为了从横断面和纵向两方面研究吸烟对心电图测量的影响，我们从规范衰老研究的702名健康男性参与者中获取了相隔5年的系列记录，这些参与者在首次检查时年龄为23至74岁。这些男性被分为当前吸烟者（在基线和随访检查时均吸烟，N = 291）、既往吸烟者（在基线检查前戒烟的男性，N = 203）或从不吸烟者（在任何时候都不吸烟，N = 208）。在基线时，当前吸烟者的P-R间期持续时间比既往吸烟者或从不吸烟者短。纵向结果表明，吸烟者的R波、S波和T波振幅下降速度比不吸烟者更快。这些发现表明，归因于衰老的心电图变化可能会因吸烟而改变。
