新生期胸腺切除对大鼠龋齿的影响。
Effect of neonatal thymectomy on dental caries in rats.
作者信息
Ebersole J L, Taubman M A, Smith D J
出版信息
Infect Immun. 1982 Dec;38(3):1130-6. doi: 10.1128/iai.38.3.1130-1136.1982.
The effect of T-cell depletion on susceptibility to dental caries after infection with Streptococcus mutans was studied. Rats were neonatally thymectomized (Tx) and infected with S. mutans 6715 or locally immunized with the homologous organism before infection. The Tx rats uniformly exhibited a higher level of infection with S. mutans and subsequently showed a greater extent of carious activity. Correlation studies were performed comparing the level of salivary and serum anti-S. mutans antibodies and the relative amount of dental caries. The results demonstrated that salivary immunoglobulin A antibody after immunization and infection, or infection only, showed a significant negative correlation with dental caries. Also, after local immunization, serum immunoglobulin G antibody showed a negative correlation with dental caries in the rats. These findings further support a major protective role for salivary immunoglobulin A in experimental dental caries in rats.
研究了T细胞耗竭对变形链球菌感染后龋齿易感性的影响。对新生大鼠进行胸腺切除（Tx），然后用变形链球菌6715感染，或在感染前用同源菌株进行局部免疫。Tx大鼠一致表现出较高水平的变形链球菌感染，随后表现出更大程度的龋活性。进行了相关性研究，比较唾液和血清中抗变形链球菌抗体水平与龋齿的相对量。结果表明，免疫和感染后或仅感染后的唾液免疫球蛋白A抗体与龋齿呈显著负相关。此外，局部免疫后，大鼠血清免疫球蛋白G抗体与龋齿呈负相关。这些发现进一步支持了唾液免疫球蛋白A在大鼠实验性龋齿中的主要保护作用。
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