新生期胸腺切除对大鼠针对变形链球菌免疫反应的影响。
Effect of neonatal thymectomy on immune responses of rats to Streptococcus mutans.
作者信息
Ebersole J L, Taubman M A, Smith D J, Frey D E
出版信息
Infect Immun. 1982 Sep;37(3):993-1000. doi: 10.1128/iai.37.3.993-1000.1982.
The effect of neonatal thymectomy on secretory and systemic antibody responses in rats was studied. Groups of normal or thymectomized (Tx) rats were infected or immunized and infected with Streptococcus mutans 6715. Tx rats exhibited a significantly lower level of salivary immunoglobulin A (IgA) antibody to S. mutans after a 45- to 65-day infection. Similarly, after multiple local injections of formalinized S. mutans, Tx rats showed a delay in the appearance and lower levels of salivary IgA antibody to S. mutans. Serum IgG antibody levels were also decreased in Tx rats with both experimental protocols. In contrast, salivary IgG and serum IgM anti-S. mutans activity in Tx and normal rats were similar during the experiments. These results demonstrated that thymus deprivation at birth produces profound effects on the ability of rats to manifest secretory IgA antibody responses to the pathogenic microorganism S. mutans.
研究了新生期胸腺切除对大鼠分泌性抗体和全身性抗体反应的影响。将正常或胸腺切除（Tx）的大鼠分组，分别进行感染或免疫并感染变形链球菌6715。在45至65天的感染后，Tx大鼠针对变形链球菌的唾液免疫球蛋白A（IgA）抗体水平显著降低。同样，在多次局部注射甲醛化变形链球菌后，Tx大鼠针对变形链球菌的唾液IgA抗体出现延迟且水平较低。在两种实验方案中，Tx大鼠的血清IgG抗体水平也降低。相比之下，在实验过程中，Tx大鼠和正常大鼠的唾液IgG以及血清IgM抗变形链球菌活性相似。这些结果表明，出生时胸腺缺失对大鼠表现出针对致病微生物变形链球菌的分泌性IgA抗体反应的能力产生了深远影响。
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