Goodman-Snitkoff G, McSharry J J
Infect Immun. 1982 Dec;38(3):1242-8. doi: 10.1128/iai.38.3.1242-1248.1982.
Purified preparations of Sindbis virus, a member of the togavirus family, are mitogenic for lymphocytes from a number of different mouse strains. Cell separation techniques, as well as studies using lymphocytes from the congenitally athymic BALB/c nu/nu mouse, showed that Sindbis virus is a T-cell-independent B-cell mitogen. Additionally, the envelope glycoproteins of Sindbis virus, isolated by Triton X-100 extraction and butanol precipitation, stimulated lymphocytes to incorporate five times as much [3H]thymidine into their DNA as did the Sindbis virion. These results are similar to those previously reported for vesicular stomatitis virus and herpes simplex virus types I and II and for the purified glycoproteins of vesicular stomatitis virus and influenza virus.
辛德毕斯病毒是披膜病毒科的成员，其纯化制剂对多种不同小鼠品系的淋巴细胞具有促有丝分裂作用。细胞分离技术以及对先天性无胸腺的BALB/c nu/nu小鼠淋巴细胞的研究表明，辛德毕斯病毒是一种不依赖T细胞的B细胞促有丝分裂原。此外，通过Triton X - 100提取和丁醇沉淀分离出的辛德毕斯病毒包膜糖蛋白，刺激淋巴细胞将[3H]胸腺嘧啶核苷掺入其DNA的量是辛德毕斯病毒粒子的五倍。这些结果与先前报道的水疱性口炎病毒、I型和II型单纯疱疹病毒以及水疱性口炎病毒和流感病毒的纯化糖蛋白的结果相似。
