流感血凝素糖蛋白及携带H2血凝素的流感病毒的促有丝分裂活性。
Mitogenicity of influenza hemagglutinin glycoproteins and influenza viruses bearing H2-hemagglutinin.
作者信息
Armstrong R B, Butchko G M, Kiley S C, Phelan M A, Ennis F A
出版信息
Infect Immun. 1981 Oct;34(1):140-3. doi: 10.1128/iai.34.1.140-143.1981.
Abstract
The hemagglutinin glycoprotein is responsible for the mitogenic effect of influenza A viruses of the H2N2 subtype. This was indicated by the ability of viruses bearing the H2-hemagglutinin glycoprotein, regardless of its associated neuraminidase, to induce lymphocyte proliferation in normal spleen cell suspensions and by the ability of antisera with specificity for the H2-hemagglutinin to block this response. Moreover, purified hemagglutinin from representative viruses from the H0N1, H1N1, H2N2, H3N2, and influenza B subtypes were also shown to be mitogenic.
摘要
血凝素糖蛋白负责H2N2亚型甲型流感病毒的促有丝分裂作用。携带H2血凝素糖蛋白的病毒，无论其相关神经氨酸酶如何，都能够在正常脾细胞悬液中诱导淋巴细胞增殖，并且对H2血凝素具有特异性的抗血清能够阻断这种反应，这些都表明了这一点。此外，从H0N1、H1N1、H2N2、H3N2和乙型流感病毒亚型的代表性病毒中纯化的血凝素也显示具有促有丝分裂作用。
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