Zöller M, Matzku S
Immunobiology. 1982 Dec;163(5):497-510. doi: 10.1016/S0171-2985(82)80063-6.
Peritoneal as well as peripheral blood, but not spleen macrophages inhibit natural killer (NK) cell activity directed against adherent growing target cells. Inhibition was observed with macrophages (Mø): spleen cell ratios as low as 0.01:1. It was independent from the activation status of Mø and was not MHC restricted. With respect to the mechanism, cell contact was essential. A cold target mechanism, reflected by some binding, but not killing, of NK cells by Mø was of minor influence. Spontaneously by Mø released soluble mediators could be excluded, nor was any soluble mediator released upon contact of Mø with spleen cells, but NK activity could be partly inhibited by supernatants from cocultures of Mø with adherent growing target cells.
腹膜巨噬细胞以及外周血巨噬细胞而非脾脏巨噬细胞会抑制针对贴壁生长靶细胞的自然杀伤（NK）细胞活性。当巨噬细胞（Mø）与脾细胞比例低至0.01:1时即可观察到抑制作用。这种抑制作用与Mø的激活状态无关，且不受主要组织相容性复合体（MHC）限制。就机制而言，细胞接触至关重要。Mø对NK细胞有一定结合但无杀伤作用所反映的冷靶机制影响较小。可以排除Mø自发释放的可溶性介质，Mø与脾细胞接触时也不会释放任何可溶性介质，但Mø与贴壁生长靶细胞共培养的上清液可部分抑制NK活性。
