一种针对HLA - A3同种抗原的单克隆抗体。

A monoclonal antibody to the HLA-A3 alloantigen.

作者信息

Bourel D, Fauchet R, Genetet B, Merdrignac G, Hurez D

出版信息

Immunol Lett. 1982 Nov;5(5):233-7. doi: 10.1016/0165-2478(82)90105-5.

Abstract

Monoclonal antibody production recognizing the HLA-A3 antigen is described. The XI-23 antibody reacted with all of the 89 cell suspensions carrying the HLA-A3 antigen (100% cytotoxicity) among a total of 191 suspensions tested. No extra-reactivity or cross-reactivity was observed, particularly with that of HLA-A11. This antibody can thus be considered as a good HLA-typing reagent.

摘要

本文描述了识别HLA - A3抗原的单克隆抗体的产生。在总共191个测试细胞悬液中，XI - 23抗体与所有89个携带HLA - A3抗原的细胞悬液发生反应（细胞毒性为100%）。未观察到额外反应性或交叉反应性，尤其是与HLA - A11的交叉反应。因此，该抗体可被视为一种良好的HLA分型试剂。