一种细胞毒性抗HLA - AB单克隆抗体，稀释后对HLA - A3交叉反应组具有特异性。

A cytotoxic anti-HLA-AB monoclonal antibody which in dilution becomes specific to HLA-A3 crossreacting group.

作者信息

Mazzilli M C, Cascino I, Porrini S C, Lavaggi M V, Lulli P, Morellini M, Testa L, Gandini E

出版信息

Tissue Antigens. 1984 Aug;24(2):107-12. doi: 10.1111/j.1399-0039.1984.tb02113.x.

DOI:10.1111/j.1399-0039.1984.tb02113.x

PMID:6208633

Abstract

XI 20.4 monoclonal antibody belongs to the IgM class. It precipitates two polypeptide chains characteristic of HLA Class I antigens. At the highest dilutions it is cytotoxic against lymphocytes carrying antigens of the HLA-A3 crossreacting group. Lysostrip experiments show that, at the lowest dilutions, the antibody reacts either with HLA-A, or B antigens.

摘要

XI 20.4单克隆抗体属于IgM类。它能沉淀出HLA I类抗原特有的两条多肽链。在最高稀释度时，它对携带HLA - A3交叉反应组抗原的淋巴细胞具有细胞毒性。溶菌酶去除实验表明，在最低稀释度时，该抗体与HLA - A或B抗原发生反应。