Deriabin I I, Samotokin B A, Khil'ko V A, Gumanenko E K, Nemchenko N S
Zh Vopr Neirokhir Im N N Burdenko. 1982 Nov-Dec(6):9-18.
The authors analysed cellular and humoral immunity in 104 patients with different types of craniocerebral injury. It was found that the T system immunity reflects the state of the main mechanisms of the organism's nonspecific resistance while its changes are determined by the level of the brain injury. A marked decrease in the T system values in the acute period of the injury with subsequent rapid restoration reflects an adequate total adaptational reaction of the organism and is characteristic of mild and moderate brain contusion. A normal or high level of cellular immunity values in the acute period of the injury with subsequent profound and prolonged immunodepression is evidence of the absence of this reaction and, consequently, of the deficiency of the nonspecific resistance mechanisms resulting from damage to the brain structures regulating these processes. Such reaction of the immune system was disclosed in severe brain contusion. The periodical character of changes in the organism's immune system after injury may serve as the basis for the therapeutic tactics.
作者分析了104例不同类型颅脑损伤患者的细胞免疫和体液免疫。发现T系统免疫反映了机体非特异性抵抗的主要机制状态，而其变化取决于脑损伤的程度。损伤急性期T系统值显著降低，随后迅速恢复，这反映了机体充分的整体适应性反应，是轻度和中度脑挫伤的特征。损伤急性期细胞免疫值正常或较高，随后出现深度和长期免疫抑制，这证明不存在这种反应，因此证明调节这些过程的脑结构受损导致非特异性抵抗机制不足。严重脑挫伤中揭示了免疫系统的这种反应。损伤后机体免疫系统变化的周期性特征可作为治疗策略的基础。
