[Status of humoral immunity in patients with severe craniocerebral injuries in the acute and late periods].

A group of 105 patients with contusion foci in the brain was studied for humoral immunity (determinations of IgA, IgG and IgM) in the process of their surgical and conservative treatment, on days 1, 7, 21, 30 and 60. and at 1, 3 and 5 years following contusion foci removal. The decreased levels of IgA, IgG and IgM were revealed at all periods of the traumatic disease. The greatest impairment of immunologic response was observed on day 1 and 7 of disease which was correlated with the severe status of patients, duration and depth of unconsciousness, the severity of general cerebral and focal symptomatology and with attendant bronchopulmonary complications. Immunological methods of investigation in conjunction with clinical ones are of great diagnostic and prognostic value.