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[颅脑创伤后期患者的免疫状态]

[Immunologic status of patients in the late period after cranio-cerebral trauma].

作者信息

Rudenko V A, Lisianyĭ N I, Chere'nko T M

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1989;89(5):28-32.

PMID:2476901
Abstract

Immune disorders characteristic of the late period of craniocerebral trauma involve T-cellular, regulatory link and were represented by a reduction of T-cells count and function with disbalance in lymphocytes-helpers, increase in macrophagal and lymphoid suppressors activity susceptible to indomethacin++. The changes also include the neurosensibilization of cellular and humoral type to brain-specific++ proteins: OBM, 14-3-2, S-100. Most pronounced changes were detected in patients after severe brain concussion with focal neural changes persisting in the late period.

摘要

颅脑创伤后期的免疫紊乱以T细胞调节环节为特征,表现为T细胞数量和功能减少,淋巴细胞辅助细胞失衡,巨噬细胞和淋巴样抑制细胞活性增加,对消炎痛敏感。这些变化还包括细胞和体液型对脑特异性蛋白(OBM、14-3-2、S-100)的神经致敏。在严重脑震荡且后期仍存在局灶性神经改变的患者中检测到最明显的变化。

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