断头后血浆儿茶酚胺的肾上腺起源：对正常和糖尿病大鼠的研究

Adrenal origin of plasma catecholamines after decapitation: a study in normal and diabetic rats.

作者信息

Berkowitz B A, Head R J

出版信息

Br J Pharmacol. 1978 Sep;64(1):3-5. doi: 10.1111/j.1476-5381.1978.tb08632.x.

DOI:10.1111/j.1476-5381.1978.tb08632.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1668258/

Abstract

The concentrations of catecholamines and the activities of dopamine-beta-hydroxylase were measured in blood obtained from decapitated diabetic and aged-matched control rats. The activity of dopamine-beta-hydroxylase in blood from diabetic rats was much greater (5 fold) than that seen for control rats. For both diabetic and control rats, decapitation was accompanied by an increase in levels of adrenaline and noradrenaline with no change in the activity of plasma dopamine-beta-hydroxylase. The results are consistent with a predominantly adrenal origin of catecholamines and extra-adrenal origin of dopamine-beta-hydroxylase. The high activity of dopamine-beta-hydroxylase in diabetes indicates either an increased activity of the sympathetic nervous system or changes in dopamine-beta-hydroxylase turnover.

摘要

对断头处死的糖尿病大鼠及年龄匹配的对照大鼠所取血液中的儿茶酚胺浓度和多巴胺-β-羟化酶活性进行了测定。糖尿病大鼠血液中多巴胺-β-羟化酶的活性比对照大鼠高得多（5倍）。对于糖尿病大鼠和对照大鼠，断头均伴随着肾上腺素和去甲肾上腺素水平的升高，而血浆多巴胺-β-羟化酶活性无变化。结果表明儿茶酚胺主要起源于肾上腺，而多巴胺-β-羟化酶起源于肾上腺外。糖尿病中多巴胺-β-羟化酶的高活性表明交感神经系统活性增加或多巴胺-β-羟化酶周转发生变化。

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本文引用的文献

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Proportional release of norepinephrine and dopamine- -hydroxylase from sympathetic nerves.去甲肾上腺素和多巴胺-β-羟化酶从交感神经的比例释放。

Science. 1971 Dec 24;174(4016):1349-51. doi: 10.1126/science.174.4016.1349.

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Photometric assay of dopamine- -hydroxylase activity in human blood.人血中多巴胺-β-羟化酶活性的光度测定

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Biochem Med. 1974 Aug;10(4):320-8. doi: 10.1016/0006-2944(74)90035-0.

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Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range.飞摩尔范围内血浆和组织中肾上腺素、去甲肾上腺素及多巴胺的同步放射酶法测定

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J Pharmacol Exp Ther. 1977 Jul;202(1):144-8.

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