Lulich K M, Paterson J W
Br J Pharmacol. 1980 Apr;68(4):633-6. doi: 10.1111/j.1476-5381.1980.tb10854.x.
1 The effect of histamine and other drugs on the central and peripheral airways of the rat was studied by applying them directly to isolated tracheal and lung strip preparations. These effects were then compared with those observed on human isolated bronchial muscle preparations. 2 Acetylcholine and 5-hydroxytryptamine (5-HT) both contracted the lung strip and trachea of the rat, and both were more potent on the trachea than the lung strip. 3 Histamine and prostaglandins E2 (PGF2) or F2 tau (PGF2 tau) produced no effect on either the lung strip or trachea of the rat. 4 On the human isolated bronchial preparation, in contrast to the rat airways, both histamine and PGF2 tau produced marked concentration-dependent contractions and 5-HT either produced no response or a slight relaxation. 5 In view of these results, the use of anaphylactic bronchoconstriction in the rat as a model for the study of asthma in man is questioned.
1 通过将组胺和其他药物直接应用于离体气管和肺条制备物，研究了它们对大鼠中央和外周气道的作用。然后将这些作用与在人离体支气管肌制备物上观察到的作用进行比较。2 乙酰胆碱和5-羟色胺（5-HT）均使大鼠的肺条和气管收缩，且二者对气管的作用比对肺条更强。3 组胺、前列腺素E2（PGF2）或F2 tau（PGF2 tau）对大鼠的肺条或气管均无作用。4 与大鼠气道相反，在人离体支气管制备物上，组胺和PGF2 tau均产生明显的浓度依赖性收缩，而5-HT要么无反应，要么产生轻微舒张。5 鉴于这些结果，有人对将大鼠过敏性支气管收缩用作人类哮喘研究模型提出质疑。
