Akabori A, Araki S, Tamada T
Endocrinol Jpn. 1981 Aug;28(4):541-5. doi: 10.1507/endocrj1954.28.541.
5-HTP (5 mg/100 g body weight), a precursor of serotonin, was administered intravenously to pituitary stalk sectioned rats. Plasma prolactin levels were initially increased 30 and 60 min after the injection of 5-HTP and thereafter decreased. Pituitary prolactin content was decreased 60 min after the stalk section as compared to those seen following sham operation. The treatment of 5-HTP induced a moderate increase in pituitary prolactin content in the stalk sectioned rats. In order to confirm the complete disconnection of pituitary stalk after the operation, 2.5 micrograms of dopamine hydrochloride was given into the lateral ventricle of stalk sectioned rats. Plasma prolactin did not change following the administration. Our results demonstrate that 5-HTP acts either directly at the pituitary level or via some mechanism yet to be determined.
5-羟色氨酸（5毫克/100克体重），一种血清素的前体，被静脉注射给垂体柄切断的大鼠。注射5-羟色氨酸后30分钟和60分钟时，血浆催乳素水平最初升高，之后下降。与假手术组相比，垂体柄切断60分钟后垂体催乳素含量降低。5-羟色氨酸处理使垂体柄切断的大鼠垂体催乳素含量适度增加。为了证实手术后垂体柄完全切断，向垂体柄切断的大鼠侧脑室内注射2.5微克盐酸多巴胺。给药后血浆催乳素没有变化。我们的结果表明，5-羟色氨酸要么直接作用于垂体水平，要么通过某种尚未确定的机制起作用。
