Nagy J, Füst G, Ambrus M, Trinn C, Paál M, Burger T
Acta Med Acad Sci Hung. 1982;39(3-4):211-8.
Fourty-four patients with IgA-glomerulonephritis (IgA GN) were studied for circulating immune complexes (IC) repeatedly in the course of disease on the evidence of four different methods suited for the detection of IC, viz. complement consumption assay, Clq-solubility test and two tests based on PEG-precipitation, and of indirect signs pointing to the presence of IC. Joint assessment of the direct and indirect signs (positivity of a minimum of 2 indirect signs or any of the direct signs) permitted to ascertain the presence of circulating IC in 72 per cent of the patients and in 63.3 per cent of the examined sera. There was no close relationship between the presence of IC and the clinical activity. On the other hand, in 16 patients positive for the rheumatoid factor (RF) the renal biopsy material revealed extensive vascular lesions. The findings suggest that the circulating IC, some of which contain RF, play a part in the pathomechanism of IgA GN and are involved in the production of the vascular abnormalities in this disease.
对44例IgA肾小球肾炎（IgA GN）患者在病程中采用四种适合检测循环免疫复合物（IC）的不同方法，即补体消耗试验、Clq溶解性试验以及两种基于聚乙二醇沉淀的试验，并根据指向IC存在的间接征象，反复研究循环免疫复合物。对直接和间接征象进行联合评估（至少2项间接征象阳性或任何一项直接征象阳性），从而确定72%的患者及63.3%的检测血清中存在循环IC。IC的存在与临床活动之间没有密切关系。另一方面，在16例类风湿因子（RF）阳性的患者中，肾活检材料显示有广泛的血管病变。这些发现提示，循环IC（其中一些含有RF）在IgA GN的发病机制中起作用，并参与了该疾病血管异常的产生。
