Rosin R D, Exarchakos G, Gilmore O J, Ellis H
Br J Surg. 1978 Sep;65(9):603-6. doi: 10.1002/bjs.1800650904.
Rats were subjected to division and anastomosis of the colon just proximal to the rectum to study the healing of colonic anastomoses. The effect of noxythiolin irrigation of the divided colon before and after anastomosis was investigated and compared with controls. Healing was assessed using five variables--macroscopic and microscopic inspection, bursting pressure and tensile strength estimations and angiography for new vessel formation. The study shows that noxythiolin irrigation of the colon in the rat significantly increases the chance of a sound anastomosis without interfering with healing. Furthermore, it inhibits the formation of adhesions.
为研究结肠吻合口的愈合情况，将大鼠直肠近端的结肠进行离断并吻合。对吻合前后离断的结肠进行诺昔硫醇冲洗，并将其效果与对照组进行比较。通过五个变量评估愈合情况——宏观和微观检查、爆破压力和抗张强度估计以及新血管形成的血管造影。研究表明，对大鼠结肠进行诺昔硫醇冲洗可显著增加吻合良好的几率，且不干扰愈合。此外，它还能抑制粘连的形成。
