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对奥斯陆地区8043名孕妇获得性弓形虫病的一项前瞻性研究。

A prospective study of acquired toxoplasmosis among 8,043 pregnant women in the Oslo area.

作者信息

Stray-Pedersen B

出版信息

Am J Obstet Gynecol. 1980 Feb 1;136(3):399-406. doi: 10.1016/0002-9378(80)90870-4.

DOI:10.1016/0002-9378(80)90870-4
PMID:6986087
Abstract

A prospective serologic study of acquired toxoplasmosis has been carried out among 8,043 pregnant women in the Oslo area by means of the DT and IgG-IFAT tests on paired blood samples collected on an average in gestational weeks 13 and 35. The screening results indicated that 54 women had to be considered as having potential "risk pregnancies" and they were selected for special follow-up studies. Thirteen women were found to have acquired a toxoplasma infection during pregnancy. The outcome of these pregnancies was: two spontaneous abortions and probably four congenitally infected children. In three of these cases parasites could be demonstrated in the placenta and/or amniotic fluid. This gives a transmission rate of 46% and an incidence of congenital toxoplasmosis of nearly 1/1,000 births.

摘要

通过对奥斯陆地区8043名孕妇进行前瞻性血清学研究,采用双倍稀释试验(DT)和免疫球蛋白G间接免疫荧光抗体试验(IgG-IFAT),对平均在妊娠第13周和第35周采集的配对血样进行检测。筛查结果表明,54名妇女被视为有潜在的“高危妊娠”,并被选作特殊的随访研究对象。发现13名妇女在孕期感染了弓形虫。这些妊娠的结局为:2例自然流产,可能有4名先天性感染儿童。其中3例在胎盘和/或羊水中发现了寄生虫。这得出的传播率为46%,先天性弓形虫病的发病率接近每1000例出生中有1例。

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Am J Obstet Gynecol. 1980 Feb 1;136(3):399-406. doi: 10.1016/0002-9378(80)90870-4.
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Drugs R D. 2017 Dec;17(4):523-544. doi: 10.1007/s40268-017-0206-8.
2
Knowledge of toxoplasmosis among doctors and nurses who provide prenatal care in an endemic region.在某地方性流行区域提供产前护理的医生和护士对弓形虫病的了解情况。
Infect Dis Obstet Gynecol. 2011;2011:750484. doi: 10.1155/2011/750484. Epub 2011 May 18.
3
Incidence of Toxoplasma gondii infection in 35,940 pregnant women in Norway and pregnancy outcome for infected women.
挪威35940名孕妇的弓形虫感染发生率及感染孕妇的妊娠结局。
J Clin Microbiol. 1998 Oct;36(10):2900-6. doi: 10.1128/JCM.36.10.2900-2906.1998.
4
Obstetric infections.产科感染
West J Med. 1981 May;134(5):394-404.
5
Congenital toxoplasmosis: epidemiologic features and control.先天性弓形虫病:流行病学特征与防控
CMAJ. 1986 Sep 15;135(6):618-23.