• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Correlation of plasma phenformin concentration with metabolic effects in normal subjects.

作者信息

Nattrass M, Sizer K, Alberti K G

出版信息

Clin Sci (Lond). 1980 Feb;58(2):153-5. doi: 10.1042/cs0580153.

DOI:10.1042/cs0580153
PMID:6987032
Abstract
  1. Circulating concentrations of intermediary metabolites have been measured after administration of 50 mg of phenformin to normal subjects. 2. Phenformin caused a significant increase in blood lactate, alanine and the lactate/pyruvate ratio but did not affect blood glucose or serum insulin concentrations. 3. There was a significant correlation between the increase in blood lactate concentration after phenformin and the plasma concentration of the drug.
摘要

相似文献

1
Correlation of plasma phenformin concentration with metabolic effects in normal subjects.
Clin Sci (Lond). 1980 Feb;58(2):153-5. doi: 10.1042/cs0580153.
2
Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics.苯乙双胍、二甲双胍和格列本脲对成年型糖尿病患者代谢节律的比较作用。
Diabetologia. 1977 Apr;13(2):145-52. doi: 10.1007/BF00745143.
3
Plasma biguanide levels are correlated with metabolic effects in diabetic patients.血浆双胍类药物水平与糖尿病患者的代谢效应相关。
Clin Pharmacol Ther. 1987 Apr;41(4):450-4. doi: 10.1038/clpt.1987.55.
4
Effect of phenformin on hepatic balances of gluconeogenic substrates in man.苯乙双胍对人体肝脏糖异生底物平衡的影响。
Diabetologia. 1978 Apr;14(4):243-8. doi: 10.1007/BF01219423.
5
[Effect of cocarboxylase on hyperlactatemia and hyperpyruvicemia induced by phenformin in dogs].
C R Seances Soc Biol Fil. 1975;169(1):121-5.
6
[Effect of sodium dichloroacetate on hyperlactatemia and hyperpyruvicemia induced by phenformin in the dog].[二氯乙酸钠对苯乙双胍诱导犬高乳酸血症和高丙酮酸血症的影响]
C R Seances Soc Biol Fil. 1976;170(4):820-4.
7
On the mechanism of action of biguanides. evidence against an inhibition of gluconeogenesis from protein in normal fasting subjects.
Horm Metab Res. 1978 Jan;10(1):1-4. doi: 10.1055/s-0028-1093468.
8
Metabolic effects of glucocorticoid and ethanol administration in phenformin- and metformin-treated obese diabetics.在接受苯乙双胍和二甲双胍治疗的肥胖糖尿病患者中糖皮质激素和乙醇给药的代谢效应
Acta Med Scand. 1979;206(4):269-73. doi: 10.1111/j.0954-6820.1979.tb13509.x.
9
Effect of obesity on circulating intermediary metabolite concentrations in the absence of impaired glucose tolerance.在未出现糖耐量受损情况下肥胖对循环中间代谢物浓度的影响。
Int J Obes. 1991 Oct;15(10):635-45.
10
Metabolic abnormalities during combined sulphonylurea and phenformin therapy in maturity-onset diabetics.成年型糖尿病患者联合使用磺脲类药物和苯乙双胍治疗期间的代谢异常。
Diabetologia. 1978 Jun;14(6):389-95. doi: 10.1007/BF01228133.

引用本文的文献

1
Metabolic modeling elucidates phenformin and atpenin A5 as broad-spectrum antiviral drugs against RNA viruses.代谢建模阐明了苯乙双胍和Atpenin A5作为针对RNA病毒的广谱抗病毒药物。
Commun Biol. 2025 May 23;8(1):791. doi: 10.1038/s42003-025-08148-y.
2
The Mechanism of Action of Biguanides: New Answers to a Complex Question.双胍类药物的作用机制：一个复杂问题的新答案
Cancers (Basel). 2022 Jun 30;14(13):3220. doi: 10.3390/cancers14133220.
3
The genetic control of phenformin 4-hydroxylation.苯乙双胍4-羟基化的遗传控制。
J Med Genet. 1985 Oct;22(5):361-6. doi: 10.1136/jmg.22.5.361.
4
Pharmacokinetic-pharmacodynamic relationships of oral hypoglycaemic agents. An update.口服降糖药的药代动力学-药效学关系。最新进展。
Clin Pharmacokinet. 1989 Feb;16(2):100-28. doi: 10.2165/00003088-198916020-00004.