Loubatières A L, Valette G, Ribes G, Rondot A M
C R Seances Soc Biol Fil. 1976;170(4):820-4.
In the normal anesthetized dog a continuous perfusion of sodium dichloroacetate (30 mg/kg.h) prevents the increase in blood lactates and pyruvates as well as the lowering of the arterial pH induced by the intraduodenal administration of phenformin (30 mg/kg). Furthermore a perfusion of sodium dichloroacetate (7.5 mg/kg.mn) during 20 minutes, three hours after the administration of phenformin, tends to improve the utilization of blood lactates and pyruvates.
在正常麻醉犬中，持续灌注二氯乙酸钠（30毫克/千克·小时）可防止因十二指肠内给予苯乙双胍（30毫克/千克）而导致的血乳酸和丙酮酸增加以及动脉pH值降低。此外，在给予苯乙双胍三小时后，持续20分钟灌注二氯乙酸钠（7.5毫克/千克·分钟），有助于改善血乳酸和丙酮酸的利用。
