鼠伤寒沙门氏菌核糖体组分的免疫原性：体液免疫分析
Immunogenicity of the ribosomal fraction of Salmonella typhimurium: analysis of humoral immunity.
作者信息
Kita E, Kashiba S
出版信息
Infect Immun. 1980 Jan;27(1):197-203. doi: 10.1128/iai.27.1.197-203.1980.
Abstract
The ribosomal fraction prepared from Salmonella typhimurium LT2 was further purified by gel filtration of Sepharose 4B and afforded excellent protection against homologous challenge. The highly effective immunogens were composed of several fractions which could give different types of protection to mice. The first type of protection was heat-labile antigens which could induce humoral immunity, and the second type of protection was heat-stable antigens capable of evoking cellular resistance in mice. The former were different from O-antigens and the latter were free of endotoxin and rich in ribonucleic acid. The third type of protection was heat-resistant substances of cell wall components, which were mainly composed of O-antigens. The high immunogenicity observed in this study could be obtained only by the heat-stable antigens rich in ribonucleic acid, and the immunity conferred by this kind of antigen was due to the cellular type of protection.
摘要
从鼠伤寒沙门氏菌LT2制备的核糖体组分通过琼脂糖4B凝胶过滤进一步纯化，并对同源攻击提供了出色的保护。高效免疫原由几个组分组成，这些组分能给小鼠提供不同类型的保护。第一种保护是可诱导体液免疫的热不稳定抗原，第二种保护是能在小鼠中引发细胞抗性的热稳定抗原。前者不同于O抗原，后者不含内毒素且富含核糖核酸。第三种保护是细胞壁成分的耐热物质，主要由O抗原组成。本研究中观察到的高免疫原性仅由富含核糖核酸的热稳定抗原获得，并且这种抗原赋予的免疫力归因于细胞类型的保护。
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