Horvath I, Kemenes F, Molnar L, Szeky A, Racz I
Infect Immun. 1980 Jan;27(1):231-4. doi: 10.1128/iai.27.1.231-234.1980.
Of 202 captive hares studied, many of which had lesions on their external genital organs or testicular atrophy or both, 27% had positive serological tests for syphilis although dark-field examination of extracts of atrophic testes was negative. A total of 12 hares that were nonreactive for the serological test for syphilis was inoculated with Treponema pallidum, 9 intratesticularly and 3 intradermally. Six of the animals inoculated intratesticularly exhibited orchitis after 7 days with an associated accumulation of treponemes. No chancres developed in the intracutaneously inoculated animals during a 27-day period of observation. These results provide additional evidence to support the contention that endemic treponematosis occurs in wild hares and suggest that hares are moderately resistant to experimental infection with T. pallidum.
在研究的202只圈养野兔中，许多野兔的外生殖器有病变或睾丸萎缩或两者皆有，27%的野兔梅毒血清学检测呈阳性，尽管对萎缩睾丸提取物进行暗视野检查结果为阴性。对12只梅毒血清学检测无反应的野兔接种梅毒螺旋体，9只进行睾丸内接种，3只进行皮内接种。7天后，睾丸内接种的动物中有6只出现睾丸炎，伴有梅毒螺旋体聚集。在27天的观察期内，皮内接种的动物未出现溃疡。这些结果提供了额外的证据来支持野生野兔中存在地方性密螺旋体病这一论点，并表明野兔对梅毒螺旋体的实验性感染有中等程度的抵抗力。
