经性传播感染兔梅毒螺旋体的家兔对梅毒螺旋体重复感染的易感性。
Susceptibility of rabbits venereally infected with Treponema paraluis-cuniculi to superinfections with Treponema pallidum.
作者信息
Graves S
出版信息
Br J Vener Dis. 1980 Dec;56(6):387-9. doi: 10.1136/sti.56.6.387.
Three female rabbits, venereally infected with Treponema paraluis-cuniculi between five and eight months previously, had treponeme-containing genital lesions and positive results to serological tests for syphilis. These rabbits and four normal female rabbits were challenged with Treponema pallidum intradermally on the shaved back with triplicate doses of 10(4), 10(3), 10(2), and 10 treponemes (all at different sites). Significantly fewer syphilitic lesions developed in the rabbits previously infected with T paraluis-cuniculi (4/36) compared with the control rabbits (37/48), and the mean size of the lesions (diameter of induration) was significantly less (4 mm compared with 10 mm). It appears that previous venereal infection of female rabbits with T paraluis-cuniculi induced a level of cross-immunity against infection with T pallidum. Protection was however not complete.
三只雌性兔子在五到八个月前通过性接触感染了兔梅毒螺旋体，它们有含梅毒螺旋体的生殖器病变，梅毒血清学检测呈阳性。这些兔子和四只正常雌性兔子在背部剃毛处皮内接种梅毒螺旋体，接种剂量分别为10⁴、10³、10²和10个梅毒螺旋体（均在不同部位），每个剂量接种三次。与对照兔子（48只中有37只出现病变）相比，先前感染兔梅毒螺旋体的兔子（36只中有4只出现病变）出现的梅毒病变明显更少，并且病变的平均大小（硬结直径）明显更小（分别为4毫米和10毫米）。看来雌性兔子先前通过性接触感染兔梅毒螺旋体可诱导一定程度的针对梅毒螺旋体感染的交叉免疫。然而，这种保护并不完全。
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