Duquesnoy R J, Annen K B, Marrari M M, Kauffman H M
N Engl J Med. 1980 Apr 10;302(15):821-5. doi: 10.1056/NEJM198004103021501.
The MB system is a newly defined system of B-cell alloantigens closely associated with HLA-DR. We assessed the role of MB compatibility in renal transplantation in a retrospective study of 21 patients who had received a kidney transplant from a related donor matched for a single HLA haplotype. One-year transplant survival was closely correlated with the presence of a compatibile MB antigen in the unshared haplotype of the donor: Eight of eight rejected kidneys were obtained from MB-incompatible donors, and 12 of 13 successful transplants were from MB-compatible donors. The association between MB compatibility and allograft acceptance was highly significant (P = 4.4 x 10(-5)), but no significant relation could be demonstrated between transplant survival and donor-recipient compatibility for antigens of the HLA-A, B or DR loci. These findings suggest that match matching for MB may be critical for the selection of donors in intrafamilial kidney transplantation.
MB系统是一个新定义的与HLA - DR密切相关的B细胞同种异体抗原系统。我们在一项回顾性研究中评估了MB相容性在肾移植中的作用，该研究涉及21例从单倍型HLA匹配的相关供体接受肾移植的患者。移植1年的存活率与供体不共享单倍型中存在相容的MB抗原密切相关：8个被排斥的肾脏均来自MB不相容的供体，13例成功移植中有12例来自MB相容的供体。MB相容性与移植物接受之间的关联非常显著（P = 4.4×10⁻⁵），但在移植存活率与HLA - A、B或DR位点抗原的供受者相容性之间未显示出显著关系。这些发现表明，在家族内肾移植中，MB配型可能对供体选择至关重要。
