Erdélyi V, Bär V, Pollák Z, Fodor J, Kralovánszky J, Tóth I, Hindy I, Eckhardt S
Strahlentherapie. 1980 Mar;156(3):198-200.
Daily doses of 1320 mg MTDQ have been administered orally to 7 patients for 100 subsequent days. Biological half-life and serum concentration measurements were performed. Function of vital organs, as well as routine laboratory findings revealed that MTDQ did not induce any toxic changes. The effect of MTDQ on the radiosensitivity of hypoxic tumor cells was studied in a combined treatment modality including 12 patients. The action on tumor regression was found encouraging. It has been found remarkable, too, that due to the effect of MTDQ and radiotherapy some of the nonspecific and general symptoms (e. g. pruritus) also disappeared.
每天口服1320毫克MTDQ，连续100天给予7名患者。进行了生物半衰期和血清浓度测量。重要器官功能以及常规实验室检查结果显示，MTDQ未引起任何毒性变化。在包括12名患者的联合治疗模式中研究了MTDQ对缺氧肿瘤细胞放射敏感性的影响。发现其对肿瘤消退的作用令人鼓舞。还发现，由于MTDQ和放疗的作用，一些非特异性和全身性症状（如瘙痒）也消失了。
