Vincenti F, Amend W J, Abele J, Feduska N J, Salvatierra O
Am J Med. 1980 Mar;68(3):363-9. doi: 10.1016/0002-9343(80)90104-7.
Atherosclerosis in 50 nondiabetic patients undergoing hemodialysis was assessed at the time of renal transplantation by intraoperative examination and histologic evaluation of the iliac vasculature. Patients were grouped accordingly: minimal (group 1), moderate (group 2) or severe (group 3) atherosclerosis. Sixty-two per cent of the patients had atherosclerosis, half of them with severe involvement. No sex differences were noted. There was a significant correlation between the patient's age and the degree of atherosclerosis (p less than 0.02). Thirty-five per cent of the patients under 30 years of age had atherosclerosis whereas similarly studied nonuremic control subjects had no atherosclerosis. Metabolic and lipid abnormalities, and duration of hemodialysis did not correlate with degree of atherosclerosis. Hypertension was present in 90 per cent of the patients in groups 2 and 3. When patients between the ages of 25 and 40 years were selected, atherosclerosis was present only in previously hypertensive patients (p less than 0.02). Atherosclerosis may not be accelerated by hemodialysis and may be prevented by more stringent control of hypertension in uremia.
在肾移植时，通过术中检查和对髂血管的组织学评估，对50例接受血液透析的非糖尿病患者的动脉粥样硬化情况进行了评估。患者据此分为：轻度（第1组）、中度（第2组）或重度（第3组）动脉粥样硬化。62%的患者患有动脉粥样硬化，其中一半为重度病变。未发现性别差异。患者年龄与动脉粥样硬化程度之间存在显著相关性（p<0.02）。30岁以下的患者中，35%患有动脉粥样硬化，而经过类似研究的非尿毒症对照受试者未患动脉粥样硬化。代谢和脂质异常以及血液透析时间与动脉粥样硬化程度无关。第2组和第3组中90%的患者患有高血压。当选择年龄在25至40岁之间的患者时，动脉粥样硬化仅出现在既往有高血压的患者中（p<0.02）。血液透析可能不会加速动脉粥样硬化，通过更严格地控制尿毒症患者的高血压，可能预防动脉粥样硬化。
