LoVerde P T, Amento C, Higashi G I
J Infect Dis. 1980 Feb;141(2):177-85. doi: 10.1093/infdis/141.2.177.
The parasite-parasite interaction of Salmonella and Schistosoma was studied. Salmonella typhimurium LT2 was found to associate in vitro with three human species of Schistosoma: Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum. Genetic mutants of S. typhimurium were allowed to interact with ligatured and unligatured worms of S. mansoni in vitro. These studies were undertaken to elucidate the mechanism(s) of the parasite-parasite interaction of Salmonella on the surface of Schistosoma. The ga/E and fla mutants showed 100% association with male schistosomes, but a reduced interaction with female worms. The rough A and pili mutants showed a significant reduction in the ability to associate with both male and female S. mansoni. Observations with the scanning electron microscope revealed that pili function in adhesion of Salmonella to the surface tegument of S. mansoni and S. haematobium. The association of Salmonella and Schistosoma may contribute to persistence of salmonella infection.
研究了沙门氏菌与血吸虫之间的寄生虫-寄生虫相互作用。发现鼠伤寒沙门氏菌LT2在体外可与三种人体血吸虫物种相关联：曼氏血吸虫、埃及血吸虫和日本血吸虫。使鼠伤寒沙门氏菌的基因变异体在体外与结扎和未结扎的曼氏血吸虫虫体相互作用。进行这些研究是为了阐明沙门氏菌在血吸虫表面的寄生虫-寄生虫相互作用机制。ga/E和fla变异体与雄性血吸虫的关联率为100%，但与雌性虫体的相互作用减少。粗糙A和菌毛变异体与雄性和雌性曼氏血吸虫的关联能力显著降低。扫描电子显微镜观察显示，菌毛在沙门氏菌黏附于曼氏血吸虫和埃及血吸虫的体表中起作用。沙门氏菌与血吸虫的关联可能有助于沙门氏菌感染的持续存在。
