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曼氏血吸虫，人体血吸虫，在其整个生命周期中都携带有细菌。

The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle.

机构信息

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy.

出版信息

J Infect Dis. 2023 Nov 2;228(9):1299-1303. doi: 10.1093/infdis/jiad288.

DOI:10.1093/infdis/jiad288
PMID:37487539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10629713/
Abstract

While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, host-pathogen interactions, and disease pathophysiology. We investigated the presence of microorganisms inhabiting tissues of the human parasite Schistosoma mansoni. In situ hybridization using a pan-bacterial 16S rRNA gene probe revealed bacteria colonizing key developmental stages that were successfully removed after antibiotic treatment of live parasites. Understanding the composition and function of the S. mansoni-associated microbiota may lead to the development of novel microbiome-targeting control strategies.

摘要

尽管无脊椎动物和细菌之间的共生关系已经被广泛描述，但对寄生蠕虫体内微生物群落的研究仍然很少。研究与引起主要传染病的寄生虫相关的微生物组将有助于了解寄生虫生物学、宿主-病原体相互作用和疾病病理生理学。我们调查了寄生于人体寄生虫曼氏血吸虫组织中的微生物的存在。使用针对细菌的 16S rRNA 基因探针的原位杂交显示，细菌定植于关键发育阶段，在对活寄生虫进行抗生素处理后，这些细菌被成功清除。了解曼氏血吸虫相关微生物组的组成和功能可能会导致开发新的针对微生物组的控制策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d31d/10629713/1737453fc72e/jiad288f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d31d/10629713/d899bbb79717/jiad288f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d31d/10629713/1737453fc72e/jiad288f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d31d/10629713/d899bbb79717/jiad288f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d31d/10629713/1737453fc72e/jiad288f2.jpg

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PLoS One. 2022 Jan 27;17(1):e0263188. doi: 10.1371/journal.pone.0263188. eCollection 2022.
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Immune Evasion Strategies of Schistosomes.血吸虫的免疫逃避策略。
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Helminth Microbiomes - A Hidden Treasure Trove?蠕虫微生物组——隐藏的宝库？
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