Pourdeihimi B, Keene J J, Gargiulo A W, Toto P D
J Periodontol. 1980 Apr;51(4):199-205. doi: 10.1902/jop.1980.51.4.199.
The localization of insulin I125 in oral tissues of the rat was investigated. Eight rats were made chemically diabetic in order to study the tissue distribution of insulin I125. Two nondiabetic control animals were also injected with the tracer. Another animal served as a complete control (i.e., not injected with either the diabetic inducer or insulin I125). Additional controls were sections of thyroid and liver. Experimental rats were sacrificed at preselected time intervals and autoradiographic procedures were performed subsequent to conventional histologic studies. Qualitative grain counts were made of each slide in order to compare with the background count. All oral tissues studied except dentin showed insulin I125 uptake.
研究了胰岛素I125在大鼠口腔组织中的定位。为了研究胰岛素I125的组织分布，使8只大鼠化学性糖尿病。还向2只非糖尿病对照动物注射了该示踪剂。另一只动物作为完全对照（即既不注射糖尿病诱导剂也不注射胰岛素I125）。额外的对照是甲状腺和肝脏切片。在预先选定的时间间隔处死实验大鼠，并在常规组织学研究之后进行放射自显影程序。对每张玻片进行定性颗粒计数以便与背景计数进行比较。除牙本质外，所有研究的口腔组织均显示摄取了胰岛素I125。
